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Prevention of clinical outcome after impacted third molar surgery in correlation with blood fibriolytic activity

Authors: Cena Dimova
PhD, MrSci, DDS, DMD, Profesor asociat, Chirurg dento-alveolar, Facultatea de Ştiinţe Medicale, Universitatea “ Goce Delcev” Stip, Conducătorul departamentului de cercetare stomatologie generală


The aim was to investigate how impacted third molar surgery, as psychophysical and operative trauma; influence the response of blood fibrinolytic system. Examined group included 50 healthy subjects with impacted third molars and 45 subjects, blood donors, as a control group. Influence of the operative interventions over parameters of blood fibrinolytic system (t-Pa and PAI-1) were examined prior the procedures and immediately after. Values of blood pressure and pulse were notified to evident physical reflections of the stress. Clinical outcome after first, second and seventh day included changes like edema, hematoma, pain and dry socket. Impacted third molar surgery, as a stress factor, had influence and affects the fibrinolysis through the effect upon the pro-activators and inhibitors of the fibrinolytic system, and the severity of the clinical outcome after operative third molar surgery. Parameters of fibrinolytic system – t-PA and PAI-1 can be the most sensitive markers of reaction to oral surgical stress…

Romanian Dental Journal © 2014