Amelogenesis and MIH – the role of MMP20 and KLK4
Enamel formation is a highly coordinated process. The enamel protein matrix, secreted by the ameloblasts, contains three main proteins: amelogenin, enamelin and ameloblastin. These proteins are specific to enamel and are degrade by specific proteases, MMP20 and KLK4. Human mutations in genes coding for the enamel proteinases cause variable degrees of hypomineralization.